Pair Name	Shogaol, Fluorouracil
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Up-regulation	Expression	ATG7	hsa10533
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	BECN1	hsa8678
	Up-regulation	Expression	CASP3	hsa836
In Vitro Model	SW480	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0546
	SW620	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0547
Result	Our data suggest that the addition of 6-shogaol to established chemotherapeutic regimens could potentially be a remarkable therapeutic strategy for colorectal cancer.

Pair Name	Shogaol, Fluorouracil
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Expression	ABCC1	hsa4363
	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	CCNA2	hsa890
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CCNE1	hsa898
	Down-regulation	Phosphorylation	MTOR	hsa2475
In Vivo Model	2×10⁶ HepG2 cells/mouse were suspended in serum-free DMEM (200 μL) and then subcutaneously inoculated into the right flank of the mice.
Result	Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer by promoting apoptosis and cell cycle arrest by regulating AKT/mTOR/MRP1 signalling